دانلود کتاب اصول تحقیقات بالینی سرطان Principles of Clinical Cancer Research, 1ed

Principles of Clinical Cancer Research provides comprehensive coverage of the fundamentals of clinical cancer research, including the full spectrum of methodologies used in the field. For those involved in research or considering research careers, this book offers a mix of practical advice and analytical tools for effective training in theoretical principles as well as specific, usable teaching examples. The clinical oncologist or trainee will find a high-yield, practical guide to the interpretation of the oncology literature and the application of data to real-world settings. Valuable for both researchers and clinicians who wish to sharpen their skills, this book contains all of the cornerstones and explanations needed to produce and recognize quality clinical science in oncology.
Written from the physician-scientist’s perspective, the book lays a strong foundation in preclinical sciences that is highly relevant to careers in translational oncology research along with coverage of population and outcomes research and clinical trials. It brings together fundamental principles in oncology with the statistical concepts one needs to know to design and interpret studies successfully. With each chapter including perspectives of both clinicians and scientists or biostatisticians, Principles of Clinical Cancer Research provides balanced, instructive, and high-quality topic overviews and applications that are accessible and thorough for anyone in the field.
KEY FEATURES:
Gives real-world examples and rationales behind which research methods to use when and why
Includes numerous tables featuring key statistical methods and programming commands used in everyday clinical research
Contains illustrative practical examples and figures in each chapter to help the reader master concepts
Provides tips and pointers for structuring a career, avoiding pitfalls, and achieving success in the field of clinical cancer research
About the Author
Associate Professor, Department of Radiation Oncology, Johns Hopkins University, Baltimore, Maryland
Contents
Chapter 1: Introduction to Clinical Cancer Research
Chapter 2: Bias and Pitfalls in Cancer Research
Chapter 3: Principles of Molecular Biology
Chapter 4: The Cell Cycler Cellular Deathr and Metabolism
Chapter 5: Metastasis and the Tumor Microenvironment
Chapter 6: Preclinical Methods
Chapter 7: Cancer Therapeutic Strategies and Treatment Resistance
Chapter 8: Prognostic and Predictive Biomarkers
Chapter 9: Working With Industry
Chapter 10: Study Designs
Chapter 11: Basic Statistics for Clinical Cancer Research
Chapter 12: Statistical Modeling for Clinical Cancer Research
Chapter 13: Cancer Epidemiology: Measuring Exposuresr Outcomesr and Risk
Chapter 14: Survivorship: Effects of Cancer Treatment on Long-Term Morbidity
Chapter 15: Longitudinal and Obsen/ational Data
Chapter 16: Time-to-Event Analysis
Chapter 17: Machine Learning and High-Dimensional Data Analysis
Chapter 18: Health Outcomes and Disparities Research
Chapter 19: Cost-Effectiveness Analysis
Chapter 20: Introduction to Clinical Trials
Chapter 21: Early Phase Clinical Trials
Chapter 22: Late Phase Clinical Trials
Chapter 23: Quality of Life and Patient-Reported Outcome Analysis
Chapter 24: Trials in Cancer Screeningr Prevention and Public Health
Chapter 25: Imaging and Technology Trials
Chapter 26: Adaptive and Innovative Clinical Trial Designs
Chapter 27: Noninferiority and Equivalence Trials
Chapter 28: Systematic Reviews and Meta-Analyses
Chapter 29: Future Directions in Clinical Cancer Research